Are nootropics safe ?

Nobody knows: If there are any good research studies comparing patients on a "brain-enhancing" substance vs. patients on a placebo, that show any real-life brain improvements (not outweighed by the substance's unknown or known side effects), then such a substance might be worthy of consideration. If no good human studies are done, then sales pitches and testimonials have nothing to stand on.

Cannot comment on safety, as these have not been approved or studied by FDA. Better question is efficacy, and there is NO solid evidence of any cognitive advantage other than some degree of subjective improved alertness on occasion, and this may well be a placebo effect. Do not waste your time or money. Most of this is fraudulent, and a frank scam.