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A female asked:

What medications show up as methadone in your system i haven't taken it why did it show up in my drug screen?

1 doctor answer3 doctors weighed in
Dr. Alan Wartenberg
A Verified Doctoranswered
Addiction Medicine 51 years experience
Several possiblities: Three commonly used medications can cause false positive methadone tests on the screening test - two antihistamines commonly used - diphenhydramine (Benadryl®) and doxylamine (Unisom®). Also, Seroquel® (quetiapine), a commonly used antipsychotic and anti-anxiety medication can do this. However, confirmatory tests should show that it is a FALSE positive.
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Last updated Jun 28, 2017

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