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A member asked:
Can ch50 & c1 esterase inhibitor be wnl with decreased c3/c4 levels? i've been diagnosed with anemia, gatroparesis, sle & mctd to date
A doctor has provided 1 answer
Yes, 2 different : conditions, and low C3/C4 is due to complement consumption in autoimmune diseases as SLE or MCTD. CH50 is the mean of hemolytic complement, and is low in complement defiency, rare, while C1 Esterase is deficient manly in Hereditary Angioedema, all not related to SLE / MCTD, wish you all the best
Answered 4/23/2017
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