Why is it that in some patients w/open angle glaucoma, the treatments aren't successful in slowing nerve damage and preventing substantial field loss?

Frustrating: Some individuals just don't quite respond well enough to conventional treatment strategies. This implies that the iop-reduction philosophy is not always the only factor beneficial to stabilizing the disease. Other factors may be genetic, blood flow, pressure-perfusion imbalances. This is when off label approaches may be attempted: ca2+ channel blockers, statins, ginkgo, limit activity that inc iop.

Protoplasm: Some patients have a week lamina cribrosa ( the structure that anchors the optic nerve in the eye). If a patient has a week structural makeup, the nerve nan stretch and be damaged at what would be considered healthy pressures in other patients.