I have mild depression but do not want to take medication. i read about sam-e. is this a safe supplement.

I think so. : That said, there are many safe & potentially effective supplements for depression such as travacor, serocor, eskaloft, deplin, & folanac. Neurotransmitter, adrenal and sex hormone testing often helps identify which supplements are most likely to help. Lifestyle adjustments-diet, sleep, activity, stress reduction, and relationship management- likewise are key. Good luck. Dr dave.