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A member asked:
I recieved 1 childhood varcella vaccine. but my labs show (-) vzv igg = non immune. how is this possible as isn't vaccination previous exposure?
A doctor has provided 1 answer
Not always effective: The varicella vaccine was approved initially as 1 dose in early childhood (>1 but <13) and 2 dose to teens or above. It is now suggested only as a 2 dose series, since about 15% will not develop long term antibodies with a single dose. Even with 2 doses, likely 5% will not. Natural varicella gives long term antibodies but no vaccine is perfect.
Answered 11/28/2017
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