44 year old man, ldl cholesterol 180. other params healthy. possible to reduce ldl without drugs?

Exercise : LDL can be lowered with diet and exercise. At that level, without any other medical problems, nonsmoking, no family members with heart disease, it is not unreasonable to do a trial of diet and exercise, but it will take a lot of work. If you have any other issues or family with heart disease, medication is warranted. Diet should be low carb, exercise should be cardio 4-5x/week.