Good question!: It is not clear why some persons respond more favorably to some antihistamines and not others. There are theories, but still not completely known. In my experience zyrtec (cetirizine) works very well for most people. Also, the approved doses of antihistamines were determined based on the minimal effective dose for the majority of people. Some persons may just need a higher dose!
Answered 5/26/2019
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