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A 28-year-old male asked:

Will taking benadryl (diphenhydramine) everyday lead to more histamine receptors? does being benadryl (diphenhydramine) everyday cause an opposite reaction and cause more allergies?

1 doctor answer1 doctor weighed in
Dr. Al Hegab
Dr. Al Hegabanswered
Allergy and Immunology 40 years experience
No: Not the case, but you may develop tolerance to the drug, meaning you have to take more to get the same result

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Last updated Jun 8, 2016

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