I was prescribed mupirocin 2% for a hole above my anus but the tube is almost gone. can i use neosporin? i've heard they're pretty much the same

Not the same: You heard wrong. Mupirocin and neosporin both are antibiotic ointments, but different antibiotics. If your doctor prescribed mupirocin, you should not substitute neosporin unless your doctor recommends it. If the "hole" persists after treatment, you might need further evaluation. For example, ask your doctor whether you might have a pilonidal sinus.

No but: Depends on the bacteria causing the infection. If mupirocin has not worked after a whole tube has been used, there is no harm in trying neosporin which is more effective on organisms other than staph. On the other hand, you also need to find out if there is a fistula (channel) between rectum and the skin near the anus when the problem is persistent. Thus a protology consult may be needed.