My wife has highbilirubin and has had it for four years but no one has ever said it was a problem, her cbc was fine except for that, what could it be?

Depends: Hyperbilirubinemia has several causes, and it depends on the level. Gilbert's hyperbilirubinemia is at the low end of elevated bilirubin and obstruction due to liver disease or damage that can cause elevation of both total and direct/indirect bilirubin. Please call the physician who ordered your test. <a href="http://www.mayoclinic.org/tests-procedures/bilirubin/basics/results/prc-20019986"