A member asked:

Does mirtazapine put one to sleep better than trazodone? trazodone doesn't work for me anymore. do they work similarly?

7 doctors weighed in across 3 answers
Dr. Ilene Ruhoy answered

Specializes in Neurology

Different mechanisms: Trazodone is a serotonin 2 antagonist/reuptake inhibitor and it blocks serotonin 2A receptors. Mirttazapine is an alpha 2 antagonist boosting both serotonin and norepinephrine. If trazodone does not work for you, mirtazapine can be tried although it is not as effective for insomnia in many. Speak with your prescribing physician.

Answered 7/13/2016

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Dr. Krishna Kumar answered

Specializes in Psychiatry

Medication effects: I understand your need for good sleep. Trazodone and Mirtazapine are not sleep medications. They are used to treat Depression. Stresses of relationships, separation, loneliness, work and past unresolved feelings of worry, fear, sadness, hurt, resentment and guilt can cause difficulty to sleep and result in poor sleep. See Psychiatrist for Diagnosis, Intensive Therapy, discuss Medications effects.

Answered 11/27/2017

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Dr. Matthew Parker answered

Specializes in Family Medicine

Check assumptions?: I agree w/ Dr Kumar, but I admit I've prescribed trazodone & mirtazapine for their sleep-inducing qualities at times. They are very different, but either can make u sleepy. I guess my question as an "holistic" doc would be: WHY can't you sleep? Do you have a sleep disorder (apnea, etc)? Are you super-stressed? Agitated? Dependent on med to make you sleep? I recommend checking every possibility.

Answered 4/23/2016

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