Acanthosis: Acanthosis nigricans is a localized skin disorder manifesting with hyperpigmented, velvety plaques located in flexural and intertriginous regions. The precise pathogenesis is unknown but is speculated to involve the stimulation of growth factor receptors on keratinocytes and fibroblasts. Acanthosis nigricans has various subtypes relating to cause and/or location: obesity-associated most commonly.
Answered 2/18/2016
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