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A 23-year-old female asked:

Can spironolactone help with water retention caused due to high estrogen levels?

1 doctor answer1 doctor weighed in
Dr. Jesse Krakauer
Endocrinology 47 years experience
Yes: B"sd spironolactone was actually developed as a diuretic - it has a hormonal mechanism of action blocking the adrenal salt retaining hormone aldosterone. It is in fact a very mild diuretic and anti-hypertensive - except when aldosterone is abnormaly high. In endocrinology we exploit a side property which is blockade of testosterone action on the skin - used for hirsuitism, acne.
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Last updated Aug 8, 2016


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