A member asked:

Can benadryl (diphenhydramine) trigger mania? every time i take it i become extremely agitated regardless of the fact that i am taking trileptal for bpd type 1.

A doctor has provided 1 answer
Dr. Heidi Fowler answered

Specializes in Psychiatry

Benadryl: Diphenhydramine has been reported to cause paradoxical reactions with symptoms of "excitation, agitation, increased energy, restlessness, nervousness, euphoria, anxiety, hallucinations, insomnia, irritability" See: https://www.drugs.com/sfx/benadryl-side-effects.html. I have not personally seen any cases where diphenhydramine alone caused a patient to flip into mania. Pseudoephedrine has =

Answered 11/15/2017

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