Swelling, history: Calf pain/soreness itself fortunately does not raise concern for a blood clot. Significant swelling of 1 leg but not the other especially in the context of recent immobilization (long flight, injury requiring hospitalization/bedrest) or surgery would suggest a risk of a blood clot in the veins of the leg. History of a clotting disorder or cancer also contributes to suspicion.
Answered 9/15/2017
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