How long does a single cortisone shot in the knee stay in one's system? longer than a week? once it has dissolved, does your body act normally again?

NoLong-TermProblems: First, the term"cortisone"could mean exactly that or, more likely,another form of it,probably more potent.So it depends on that but also, what's called the "clinical benefit"to you,not just the supposed"half life."I know a few people in whom it"helped"for several months. But who knows, there's lots of variables.But if you want a simple answer,a steroid injection into a joint"should" last 4-8 weeks