If norepinephrine increases restlessness and anxiety, among other effects, how can effexor (venlafaxine) be a treatment for anxiety?

Synergy: Effexor (venlafaxine) and Effexor (venlafaxine) XR are In the category of SNRIs -serotonin and norepinephrine reuptake inhibitors. This results in enhancement of both in areas of the brain associated with depression and anxiety . Serotonin works by calming the brain while norepinephrine increases alertness. It is thought that the synergistic effect of both promotes antianxiety effect along with antidepressant effects.