PPI delayed; H2 fast: PPIs do not usually work immediately and can take several days to a week in the worst case. H2 blockers like Pepcid and Zantac (ranitidine) work much more quickly, within hours. Both of these decrease production of new acid. For immediate relief you need chemical neutralization of existing acid with e.g. Pepto-Bismol or Mylanta/Maalox.
Answered 9/17/2015
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