Is it possible recurrence of thyroid cancer if thyroglobulin came back positive but antibodies are decreasing? had full thyroidectomy 2 years ago.

Need an exam : Thyroglobulin is one of the markers used in follow up. A rise in the value would prompt you to see an Oncologist for a clinical exam, repeat the labs and if necessary order tests like a radio active scan depending on the type of thyroid cancer

Recurrence: Rest assured. It is impossible to say you are cancer free, but that is likely. Here's why: the thyroglobulin level is unreliable because you have antibodies. The fact that the antibodies are decreasing can mean that thyroglobulin is decreasing. Antibodies can be a tumor marker surrogate. Continue to follow the antibody trend and get periodic neck ultrasounds.