A member asked:

How spironolactone decreases testosterone production in a pcos woman?

A doctor has provided 1 answer
Dr. Dennis Higginbotham answered

Specializes in American Board of Obstetrics and Gynecology

It doesn't: Spironolactone is a diuretic that also happens to block testosterone receptors in hair follicles. Since many women with P COS experience some degree of hirsutism as a result of the elevated testosterone common with PCOS the Spironolactone is prescribed to block the receptors to prevent those hair changes. The testosterone production can be decreased by suppressing the ovaries with OCP's.

Answered 4/11/2019

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