I have suffered from generalized anxiety syndrome and depression. for years. i was on paxil for 12 years symptom free, but because of weight gain was put on zoloft five years ago, which gave up after 2 years. then lexapro, which worked for only 1 year,

Therapy?: Have you yet tried any form of psychotherapy? Typically, the optimal combination of things to treat emotional issues such as depression is medication (which, on your best day, is supposed to take the edge off symptoms) but the real gruntwork takes place in psychotherapist's consulting room.

Additional info need: Your question was cut off. I assume you are under the care of a psychiatrist. It may be helpful to consult with another provider if you feel you need a second opinion. Also, therapy is very helpful talking through your concerns.