Took fioricet (acetaminophen butalbital and caffeine) for my tension migraine. how long will it stay in my system?

Fioricet (acetaminophen butalbital and caffeine) 1 day only: doesn't stay in the blood long-term. The average "half-life" of fioricet, (acetaminophen butalbital and caffeine) which means the time it takes the blood to eliminate half of the drug is 4.5 hours. It takes approximately 6 half lives for a drug to be eliminated from your system 4.5*6/24= 1.12 day. Fioricet (acetaminophen butalbital and caffeine) can cause medication overuse headache. See your PCP for headache management.