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A member asked:
Will over-the-counter antihistamines like benadryl (diphenhydramine) have any bad interactions with ssris like zoloft?
A doctor has provided 1 answer
Generally no: Second generation antihistamines such as allegra, zyrtec and Claritin are non sedating and do not interact with ssris. Benadryl (diphenhydramine) is sedating and may increase the sedation of ssris.
Answered 2/25/2017
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