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A member asked:

Will over-the-counter antihistamines like benadryl (diphenhydramine) have any bad interactions with ssris like zoloft?

A doctor has provided 1 answer

Generally no: Second generation antihistamines such as allegra, zyrtec and Claritin are non sedating and do not interact with ssris. Benadryl (diphenhydramine) is sedating and may increase the sedation of ssris.

Dr Pappas and 2 doctors agreed

Answered 2/25/2017

5.2k views

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