Get Virtual Care
For Businesses
About Us
A member asked:
Is it safe to take zoloft and benadryl (diphenhydramine)? i noticed they both have hydrchloride.
2 doctors weighed in across 2 answers
OK but Caution: Benadryl (diphenhydramine) together with sertraline may increase side effects such as dizziness, drowsiness, & difficulty concentrating. Some people may also experience some impairment in thinking & judgment. You should avoid/limit use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Max Benadryl (diphenhydramine) dose is 300mg/d.
Answered 1/28/2021
5.2k views
Yes: The chloride is just the salt which gets rapidly eliminated. Zoloft raises serotonin. Benadryl (diphenhydramine) is an antihistamine which is unrelated.
Answered 6/15/2018
5.2k views
Related Questions
A member asked:
Accidentally give my liver too much? Had 1/4 glass of wine. Then 3 hrs later, not thinking, took a Benadryl (diphenhydramine) for allerg and 25 mg of prs Zoloft for anx
4 doctors weighed in across 2 answers
A member asked:
Can I take benadryl, (diphenhydramine) buspirone, and sertraline together? Before bed? I know it will probably increase drowsiness, I just want to make sure it's safe.
A doctor has provided 1 answer
A member asked:
Can I take sleep-eze 25mg diphenhydramine hydrochloride Tablets while on 50 mg sertraline, but in a couple days its going up to 100mg. But is it safe? just until my next appointment with my psychiatrist?
2 doctors weighed in across 2 answers
A member asked:
Can I take Zoloft and Allegra in the morning and then Benadryl before bed?
A doctor has provided 1 answer
A member asked:
I take Sertraline HCL 50 MG and Trazodone 150 MG Is it ok to take Benadryl (diphenhydramine) allergy liqui-Gels 25 MG with the other meds?
9 doctors weighed in across 3 answers
People also searched for:
I've been on 50mg of Zoloft a day since june. How much Benadryl (diphenhydramine) can I safely take?
Can I take Benadryl (diphenhydramine) while taking Zoloft? I take my Zoloft every night at 930 so would it be fine to mix the two?
I just started zoloft today along with Buspirone and have a headache, can I take a benadryl (diphenhydramine)?
Are diphenhydramine and Zoloft (sertraline) bad to take together?
I am on 50mg of Zoloft (sertraline) for anxiety and wondering if i can take diphenhydramine to help me sleep. I worry about them interacting but i can't sleep:(?
Didn't find what you're looking for?
90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.
Ask your questionMore of what we treat
Download HealthTap
Video visit and message your doctor
