Accidentally give my liver too much? had 1/4 glass of wine. then 3 hrs later, not thinking, took a benadryl (diphenhydramine) for allerg and 25 mg of prs zoloft for anx

Liver likely ok: Although alcohol, Benadryl (diphenhydramine), and Zoloft (sertraline) are all broken down by the liver, the quantities you mention shouldn't be a problem for an otherwise healthy liver. But I'm a little concerned if you take Zoloft "prn" (as needed) for anxiety. It doesn't work well that way, although it can relieve anxiety if taken daily. Talk to your prescribing doctor about this.

Dr Altman and another doctor agreed

Ok for healthy liver: Unless you have chronic liver disease, your liver v should be able to handle this combination of substances.