I have started getting facial swelling (adema) that lasts for days after running, drinking alcohol or coffee. what is causing this, my adrenals?

Worthy to check it: Swelling due to fluid accumulation in a tissue, or edema, could be caused by problems with the adrenal glands. These conditions are relatively rare, however, compared to other causes related to the kidney, liver, lymphatics or blood vessels. I would suggest seeing your physician for an examination and blood work for starters. Further investigation with radiologic studies may also be warranted.