What is cushing disease ?

Endocrine disease: Cushings disease is excess glucocorticoids produced by the adrenal glad. This leads to central obesity, proximal muscle weakness, fatigue, buffalo hump. The adrenal is stimulated by adrenocorticotropic hormone produced in excess by a pituitary tumor in cushings disease. Cushings syndrome is adrenal excess by other mechanisms including exogenous intake.

Disease vrs Syndrome: Cushing disease, which is hypercortisolism caused by an acth-secreting pituitary adenoma, is the most common cause of cushing syndrome, and is responsible for 60% to 70% of cases. Cushing syndrome is mainly caused by other sources of corticosteroids like the medicines dr prescribe to treat many conditions ( prednisone, medrol, (methylprednisolone) solumedrol, (methylprednisolone) deposed rol, etc) commonly in copd, asthma, allergies.