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A member asked:
My brother has alpha 1 antiitrypsin gene with his liver affected, awaiting my own results ..what are my odds of having it? should my kids be tested?
A doctor has provided 1 answer
Variable: Alpha 1 antitrypsin disease results (usually) when two unaffected carriers donate their recessive gene to the offspring. With 2 abnormal genes, the medical condition can be expressed. If you share the same parents, you have 3 potential outcomes. Normal,with two normal genes; a carrier with one normal and one abnormal: or you have it but don't know it(unlikely). 2:1 carrier than normal
Answered 4/28/2015
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