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A 34-year-old female asked:

I'm having negative dna ,sm and rnp antibodies, but positive sm/rnp antibody,and high ana titre speckled,so what is the diagnosis ?

1 doctor answer2 doctors weighed in
Dr. Stuart Winkler
Internal Medicine - Nephrology & Dialysis 50 years experience
Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist.
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Last updated Apr 20, 2015

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