A 39-year-old female asked:
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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

1 doctor answer
Dr. Stuart Winkler
47 years experience in Nephrology and Dialysis
Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist.
Answered on Apr 20, 2015
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Related questions:

A 41-year-old female asked:
Dr. Ronald Krauser
51 years experience in Rheumatology
Possibly nothing: The ANA screen is positive but one needs a full titer and pattern to know what it means. The other results are flatly negative.
A 41-year-old female asked:
Dr. Ronald Krauser
51 years experience in Rheumatology
Yes: Remember, the ANA by itself means nothing. You need clinical criteria consistent with lupus to actually have lupus.
A 43-year-old female asked:
Dr. Ed Friedlander
43 years experience in Pathology
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but i ... Read More
A female asked:
Dr. Ronald Krauser
51 years experience in Rheumatology
Unrelated: Fatigue alone is not lupus. A DNA alone is not diagnostic.

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