How long does it take to lose your appetite when taking wellbutrin (bupropion)?

It depends: While Wellbutrin (bupropion) is considered a weight neutral antidepressant, losing one's appetite is not necessarily expected. However, you will be less likely to gain weight from it. If your depression has led to a weight gain due to emotional eating, you may find that the urge to eat like that will decrease as the medicine reduces your depression.