A member asked:

I've just seen on the internet that trazadone and amitriptyline taken together is dangerous, opinions please?

2 doctors weighed in across 2 answers

Problematic: It is simplistic to say "dangerous," although that particular combination sounds problematic. The degree of risk would be dose-dependent. The interaction would likely include synergistic sedation, requiring clinical warning, and additional synergistic side effects, such as weight gain. But the combination raises questions about appropriateness: possibly a poor choice in an augmentation strategy.

Answered 6/21/2016

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Dr. Alan Ali answered

Specializes in Psychiatry

Trazodone/Elavil: At high doses, can be overly sedating. Lower doses of 25-50mg. each should be ok. Keep in mind that addition of pain medications adds to the sedation.

Answered 4/7/2015

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