Liver enymes high, alt 105 and ast 69, have lost 51lbs and not overweight. thought?

Need a workup: Congratulations on your weight loss. You need to address the possible causes of the elevated liver enzymes. You may be asked to repeat the test off all medications and alcohol. If still up, we'll rule in-or-out hepatitis B and C, hemochromatosis, Wilson's, autoimmunity. This may simply be metabolic syndrome, perhaps best managed with a return to a fitness-focused lifestyle -- yours is a good start