See Allergist: Intermittent swelling with unknown trigger could be a sign that you have idiopathic angioedema (CIA). Common triggers include heat, cold, and viral infections. CIA is more common in females, average age of onset between 30-50yrs. Medications like ACE-inhibitors can also cause random swelling. Trial of daily antihistamines like Zyrtec (cetirizine) can be beneficial, screening C4 level can help reveal cause.
Answered 3/30/2021
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