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A member asked:
What is the physical basis of mutational hotspot?
A doctor has provided 1 answer
Largely unknown: For this answer, you'll need a treatise on the arcana of the physical chemistry of nucleic acids. It's not something the healthtap team has time to think about often in the hurly-burly of clinical medicine, but we are aware that today's medicine depends on the discoveries of the molecular geneticists. Try a graduate level textbook of genomics.
Answered 4/4/2013
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