Why os the prognosis for aml subtype m0 worse?

AML m0 type: Prognosis of AML depends upon the age of patient, comorbid conditions and how they can tolerate and navigate through the induction and consolidation therapies. Some cytogenetic features also impart worse prognosis. Type m0 is highly treatable and good chance of a therapeutic response. Stem cell transplant eval should also be done at a bigger center.

French American and: British (FAB) pathologists previously got together to classify Acute Myeloid Leukemia (AML) according to the microscopic appearance. They came up with 8 types based on the staining pattern (M0-M7). Other than M3 (aka acute promyelocytic leukemia) the FAB class is not very helpful at determining prognosis or optimal treatment. Cytogenetics and molecular studies have mostly supplanted this.