An autopsy revealed 1070 grams brain atrophy, is that a significant amount?

Not clear: Brain atrophy occurs in many conditions, and is secondary to the underlying pathology, such as alzheimer's in older people, or multiple sclerosis in younger pts. As we age, our brains decrease in size due to the normal aging process. This has to be placed in context, per age, cause, size of person, etc.

Depends ...: Average brain weight in males is 1336 g, while in females it is 1198 g. As age increases in adulthood, brain weight decreases due to natural aging 2.7 grams/year in males and 2.3 grams in females. If this brain was from an average size man, i would think it is probably more atrophy than seen in normal aging, however, in a small, elderly female, it could possibly be seen as normal aging.