Sertraline(150 mg per day)&bupropion(200 mg per day)combination increased my appetite, which one is the most likely cause of this problem?best regards.

?: Many psychiatric medications can be associated with wt gain. Both of these are much less likely than most and in fact wt loss and loss of appetite is listed as a common side effect for both, but everybody is a little different. Might want to look at other possible factors such as residual depression.

Sertraline: Between these 2 antidepressants, sertraline is by far the more likely to cause increased appetite and wt gain. Bupropion often will cause the opposite.