Is it safe to take 2500mg tylenol (acetaminophen) daily long term? is it also safe to take that long term during pregnancy?

Tylenol (acetaminophen) Toxicity: The simple answer to your question is no. Tylenol (acetaminophen) is very toxic in high and regular doses to your liver. I am not sure why you are taking this daily and would advise you to get to your obstetrician to make sure they are aware of this and to give them a chance to discuss healthier options for you.