Daughter had hsp couple yrs ago and now has joint pain agsin no rash but pos ana and moderately high esr. is this connected? if not what else can be

May be connected!: Good morning, i can understand the reason for the worry about the positive ANA and high ESR following hsp, which represents an immune-mediated vasculitis, which is an inflammation triggered by an antigen such as a virus infection. The presence of ANA and high ESR shows continued hyperactivity of immune system. As an immunologist, i recommend a follow-up by a rheumatologist to keep an eye on ana.

Rheumatology!: See a rheumatologist. A doctor in this speciality is most likely to figure it out. An exam with your history and lab tests will be needed.

No: Positive ANA may suggest rather a different type of vasculitis. She should see a pediatric rheumatologist for further evaluation.