A member asked:

I tested positive for harmful brca 2 mutation....so unsure what to do

17 doctors weighed in across 3 answers

Genetic Counseling: Have you met with a genetic counselor? If not, i strongly recommend this. Testing brca-2 (+) puts you at an increased risk for breast and ovarian cancer (as well as ca of the stomach, pancreas, gallbladder, bile ducts, and melanoma). Options include surgical prophylaxis (mastectomy, oophorectomy), chemoprevention, and close surveillance. These decisions are best made with a professional.

Answered 1/16/2014

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Dr. Todd Sisto answered

Specializes in Plastic Surgery

Two main choices: See an oncologist and get on tamoxifen or similar rx x 5 yrs plus monthly self exam & frequent mammograms or usg/mri(need special MRI machine for ca screening).Or see asps plastic surgeon for prophylactic subcutaneous mastectomy & reconstruction. Some cases, breasts look as good or better than preop, but nipple sensation is always lost. Your mom/sisters/daughters must get tested!

Answered 4/25/2015

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Dr. Devon Webster answered

Specializes in Medical Oncology

Early screening: Genetic counseling is key! you need to examine your breasts monthly, and have a doctor examine them every 6 months. You need yearly mammograms and breast mris, and vaginal ultrasounds and ca125 testing every six months. If you want children, do it as soon as possible, and talk to your doctor about when to have your ovaries removed. Ideal is between 35-40.This is a lot of info; find an advocate!

Answered 12/25/2014

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