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A 29-year-old member asked:

I tested positive for harmful brca 2 mutation....so unsure what to do

3 doctor answers17 doctors weighed in
Dr. Barry Rosen
General Surgery 36 years experience
Genetic Counseling: Have you met with a genetic counselor? If not, i strongly recommend this. Testing brca-2 (+) puts you at an increased risk for breast and ovarian cancer (as well as ca of the stomach, pancreas, gallbladder, bile ducts, and melanoma). Options include surgical prophylaxis (mastectomy, oophorectomy), chemoprevention, and close surveillance. These decisions are best made with a professional.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Michael Zadeh
General Surgery 19 years experience
Agree with Dr. Rosen. This is one of the few situations in which I encourage prophylactic mastectomy. Not only should you be closely followed, but if you have any children you should also make sure they get tested for the mutation too.
Jan 14, 2012
Dr. Raymundo Romero
Medical Oncology 24 years experience
Very good advice. I encourage you to speak to all your relatives, they need to get checked too. Let's not forget the men, BRCA2 is associated with male breast cancer, prostate cancer and pancreatic cancer.
Jan 28, 2012
Dr. Todd Sisto
Plastic Surgery 39 years experience
Two main choices: See an oncologist and get on tamoxifen or similar rx x 5 yrs plus monthly self exam & frequent mammograms or usg/mri(need special MRI machine for ca screening).Or see asps plastic surgeon for prophylactic subcutaneous mastectomy & reconstruction. Some cases, breasts look as good or better than preop, but nipple sensation is always lost. Your mom/sisters/daughters must get tested!
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Dr. Devon Webster
Medical Oncology 24 years experience
Early screening: Genetic counseling is key! you need to examine your breasts monthly, and have a doctor examine them every 6 months. You need yearly mammograms and breast mris, and vaginal ultrasounds and ca125 testing every six months. If you want children, do it as soon as possible, and talk to your doctor about when to have your ovaries removed. Ideal is between 35-40.This is a lot of info; find an advocate!
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Apr 25, 2015


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