A member asked:

I had a normal first trimester screening and harmony prenatal test. is an afp blood test necessary? can it come back high risk?

2 doctors weighed in across 2 answers

It is different.: First trimester screens and the harmony test are for chromosomal abnormalities. The AFP tests for neural tube defects (spina bifida).

Answered 1/31/2015

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Dr. Jie Xu answered

Specializes in Obstetrics and Gynecology

The msAFP is: To assess the risk of open neural tube defects i.e. Spina bifida, which is not tested by harmony or the first trimester screen. It is up to you if you would like to be screened for ntds. Keep in mind that, if detected, these defects can be repaired by a skilled pediatric neurosurgeon while the baby is still inside you. Speak to your obgyn and make an informed decision. Hope this helps.

Answered 1/31/2015

5.3k views

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