Is there a way to prevent or cope w/ "buzzed" feeling in head from weekly methotrexate dose? currently taking on tues & want to switch to weekend.

Not common side efct: That is not a common side effect in my experience with Methotrexate but there are a variety of possible side effects.Most of the side effects of Methotrexate improve over time in most patients so it may improve over time.Taking the Methotrexate on the weekend is a good idea since many of the common side effects such as fatigue or nausea won't interfere with going to work or school.Talk to your doc.