A member asked:

Is it best to take oral methotrexate on empty stomach or ok 2 take with full meal 2 prevent nausea? my doc didn't specify but i read different views.

A doctor has provided 1 answer

Dr. Larry Greenbaum answered

Specializes in Internal Medicine - rheumatology

Take folic acid !: You can take the Methotrexate with food, but you should also take Folic Acid daily to prevent GI side effects. The Folic Acid is an inexpensive b vitamin and will not decrease the effectiveness of the methotrexate. I usually start patients on 1mg of Folic Acid a day, but some patients need more.

Answered 6/26/2018

5.3k views

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A member asked:

Is it best to take oral methotrexate on empty stomach or ok 2 take with full meal 2 prevent nausea? my doc didn't specify but i read different views.

A doctor has provided 1 answer

Dr. Larry Greenbaum answered

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