A member asked:

Can barretts metaplasia (no dysplasia) progress directly to adenocarcinoma of esophegus within 4 months of egd scopy?

A doctor has provided 1 answer

Unlikely: Does your question signal that it did happen? Even if biopsies are negative for dysplasia, biopsies are just that, biopsies of a larger lesion. Biopsies always have the chance of having sampling error...Meaning the most severe part of the lesion was not sampled. The risk of sampling error would go up with a larger lesion than was minimally, and not systematically, biopsied.

Answered 2/3/2019

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