What can be done for poorly differentiated adenocarcinoma arising in the setting of intestinal metaplasia?

CUP?: Cancer 1-2-3 -- 1) diagnosis -- we know cancer , but what kind? May need additional information -- is this a colon polyp, now cancer or what? Pathologist can help and may need special testing. 7% of cancers have know known primary (cup or upc). 2) staging and prognostic factors. 3) treatment. Need all of the pieces of the puzzle before treating.