A member asked:

Does kinefelter's syndrome increase the risk of breast cancer?

4 doctors weighed in across 2 answers

Yes: Men with klinefelter's syndrome (xxy) have lower levels of androgens and higher levels of estrogen. As a result, these patients may develop breast tissue and are at higher risk for developing male breast cancer.

Answered 2/6/2013

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Dr. Devon Webster answered

Specializes in Medical Oncology

Yes, it does: Klinefelter syndrome refers to a genetic condition where a male inherits two x chromosomes in addition to the y chromosome (xxy). This causes lower levels of male hormones (testosterone) and higher levels of female hormones (estrogens). Men with klinefelter syndrome often have prominent breast tissue, smaller penises and testicles, and they do have a higher risk of developing male breast cancer.

Answered 12/9/2013

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