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A member asked:
Do selective adeno-adenergic blockers (prazosin, terazosin, doxazosin, trimazosin) protect from acute cocaine-induced vasoconstrictive damage?
8 doctors weighed in across 2 answers
Some: Cocaine causes it's effect by preventing the reuptake of monamine (epinephrine, etc) and causes these neurotransmitters to continue exciting the a1 receptor. The meds listed block alpha-1 receptors, so theoretically will blunt the effects of Cocaine on some vessels, but focus mostly (esp. Tamsulosin) on a specific sub-type (alpha-1a) that is mostly in the bladder, not in the vessels.
Answered 6/24/2014
6.1k views
Probably not: I am unaware of any studies of this, but the mechanism by which Cocaine causes vasoconstriction is very different than the mechanism by which these drugs cause vasodilation.
Answered 6/24/2014
4.9k views
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