How do you get rid of a puss filled blister on the top of your toe? is it serious? how long does it take to go away?

See a doctor : A pus filled blister is a sign of a significant infection and should be evaluated and treated. An infection on the foot can become serious very quickly.

Blister and pus: Please see a dermatologist to evaluate and aseptically with sterile disinfectants and sterile needles or a lance, can extract the content out of the blister which may help make it feel more comfortable if it's been hurting. Furthermore, they may prescribe an antibiotic for you if they think it is infected. Don't do this yourself.

Infection: This could be a very serious infection and could get worse very quickly. You should see a dermatologist for evaluation and treatment. They may take a culture, put you on oral and topical antibiotics, and advise you on proper wound care. While waiting to see the doctor, apply a topical otc antibiotic ointment (ie: polysporin, (bacitracin and polymyxin) neosporin), avoid wearing tight fitting shoes, limit activity.

Other diseases: Why did you develop an abscess? It is important to seek care immediately especially if you have diabetes or peripheral vascular disease or neuropathy.