A member asked:

Ana past 4 x's postitive but low titers 40, 80 and once 160 now negative what's that indicate?

A doctor has provided 1 answer

Likely, not much: Anas are not infrequently identified in healthy individuals in low titres that may disappear at intervals. Detection of anas is variably sensitive in detection of autoimmune (ai) or rheumatic disease (rd), and may be falsely positive in normal women, the elderly and first degree relatives of patients with ANA + ai disease. Interpretation needs to account for ANA pattern, titre and clinical symptom.

Answered 6/10/2014

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