Likely, not much: Anas are not infrequently identified in healthy individuals in low titres that may disappear at intervals. Detection of anas is variably sensitive in detection of autoimmune (ai) or rheumatic disease (rd), and may be falsely positive in normal women, the elderly and first degree relatives of patients with ANA + ai disease. Interpretation needs to account for ANA pattern, titre and clinical symptom.
Answered 6/10/2014
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